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ISSN 2218-4333 World Journal of - Microsoft .ISSN 2218-4333 (online) PRESIDENT AND EDITOR-IN-

Published by Baishideng Publishing Group Inc

World Journal of Clinical OncologyWorld J Clin Oncol 2015 December 10; 6(6): 184-311

ISSN 2218-4333 (online)

PRESIDENT AND EDITOR-IN-CHIEFGodefridus J Peters, Amsterdam

GUEST EDITORIAL BOARD MEMBERSWei-Fan Chiang, TainanChien Chou, TaipeiShuang-En Chuang, Zhunan TownshipWen-Liang Fang, TaipeiChao-Cheng Huang, KaohsiungHuang-Kai Kao, TaoyuanChun-Yen Lin, KweishanJun-Yang Liou, ZhunanSee-Tong Pang, TaoyuanNeng-Yao Shih, Tainan Che-Chun Su, ChanghuaHao-Wei Teng, TaipeiKuo-Wang Tsai, Kaohsiung

MEMBERS OF THE EDITORIAL BOARD

Argentina

Marina Simian, Buenos Aires

Australia

David Alexander Brown, SydneyBelamy B Cheung, SydneyAngela Hong, SydneyHelen Kavnoudias, MelbourneKum Kum Khanna, BrisbaneFeng Pan, Hobart

Austria

Andreas Leithner, Graz

Okay Saydam, Vienna

Belgium

Grald E Pirard, Lige

Brazil

Katia Ramos Moreira Leite, Sao Paulo

Bulgaria

Julian Ananiev, Stara Zagora

Canada

Slimane Belbraouet, MonctonFrancesco Crea, VancouverSharlene Gill, VancouverAnil Kapoor, HamiltonSaroj Niraula, WinnipegSiyaram Pandey, Windsor

China

Nian-Yong Chen, ChengduJames CS Chim, Hong KongWilliam Chi-shing Cho, Hong KongYong-Song Guan, ChengduYi Ji, ChengduFu Li, TianjinLin-Wei Li, ZhengzhouXin-Xiang Li, ShanghaiLiu Liu, HefeiYun-Ping Luo, Beijing

Mao-Bin Meng, TianjinTzi Bun Ng, Hong KongYang-Lin Pan, XianXiu-Feng Pang, ShanghaiShu-Kui Qin, NanjingXiao-Juan Sun, ShenzhenJian Suo, ChangchunXing-Huan Wang, WuhanYun-Shan Yang, HangzhouLei Yao, ShanghaiPei-Wu Yu, ChongqingYin-Hua Yu, ShanghaiGuo Yu, YangzhouKe Zen, NanjingLi-Duan Zheng, WuhanZhao-Hua Zhong, HarbinHai-Meng Zhou, BeijingSen-Lin Zhu, GuangzhouHong-Qing Zhuang, Tianjin

Cuba

Elia Neninger, Havana

Denmark

Pavel Gromov, CopenhagenAndreas Kjaer, CopenhagenCathy Mitchelmore, RoskildeHenrik Toft Sorensen, Aarhus

France

Gilles Houvenaeghel, MarseilleFabrice Lecuru, ParisClara Nahmias, VillejuifPalma Rocchi, Marseille

Editorial Board2015-2018

The World Journal of Clinical Oncology Editorial Board consists of 293 members, representing a team of worldwide experts in oncology. They are from 41 countries, including Argentina (1), Australia (6), Austria (2), Belgium (1), Brazil (1), Bulgaria (1), Canada (6), China (42), Cuba (1), Denmark (4), France (4), Germany (11), Greece (1), Hungary (1), India (7), Iran (2), Ireland (1), Israel (1), Italy (33), Japan (25), Malaysia (3), Netherlands (8), Norway (3), Peru (1), Poland (1), Portugal (2), Qatar (1), Romania (1), Russia (1), Saudi Arabia (3), Singapore (2), South Korea (12), Spain (11), Sri Lanka (1), Sweden (2), Switzerland (1), Syria (1), Turkey (7), United Kingdom (3), United States (77), and Viet Nam (1).

February 10, 2015WJCO|www.wjgnet.com

World Journal ofClinical OncologyW J C O

Germany

Malgorzata Banys-Paluchowski, HamburgAlexandr Bazhin, MunichWolfgang M Brueckl, NurembergKlaus Felix, HeidelbergJan G Hengstler, DortmundJorg Kleeff, MunichMichael Pinkawa, AachenDaniel Reim, MunichRajkumar Savai, Bad NauheimManfred Schmitt, MunichJurgen Veeck, Aachen

Greece

Vasilis Androutsopoulos, Heraklion

Hungary

Zsuzsa Schaff, Budapest

India

Imran Ali, New DelhiSudhir Chandna, DelhiSubhojit Dey, GurgaonSachin B Ingle, LaturChanakya Nath Kundu, BhubaneswarSyed Musthapa Meeran, IucknowSuprava Patel, Raipur

Iran

Mojgan Hosseini, TehranAli Kabir, Tehran

Ireland

Michael Joseph Kerin, Galway

Israel

Rina Rosin-Arbesfeld, Tel Aviv

Italy

Luca Arcaini, PaviaLuigi Bagella, SassariGiovanni Blandino, RomeGuido Bocci, PisaGuido Cavaletti, MonzaFulvio Chiacchiera, MilanAnita De Rossi, PadovaGiuseppe Di Lorenzo, NapAPOLINicola Fazio, MilanGiammaria Fiorentini, PesaroRobert Fruscio, MonzaMarilena Valeria Iorio, MilanMarco La Torre, RomeMatteo Landriscina, Foggia

Giuseppe Lombardi, PaduaMonica Mangoni, FlorenceMichele N Minuto, GenoaSimone Mocellin, PadovaLuca Mologni, MonzaMassimo Nabissi, CamerinoSilvio Naviglio, NaplesNicola Normanno, NaplesFrancesca Pentimalli, AvellinoRoberto Petrioli, SienaGiuseppe Procopio, MilanTiziana Rancati, MilanGian-Luigi Russo, AvellinoBruna Scaggiante, TriesteAlessandro Sciarra, RomeGiuseppe Servillo, PerugiaGilbert Spizzo, MeranoRoberta Venturella, CatanzaroGiovanni Vitale, Cusano Milanino

Japan

Ujjal K Bhawal, MatsudoXing Cui, ChibaTakanori Goi, Yoshida-gunShuichi Hironaka, ChibaMikito Inokuchi, TokyoHideki Kawai, AkitaNaoko Iwahashi Kondo, FukuokaHiroki Kuniyasu, KashiharaShoji Nagao, AkashiJun Nakamura, SagaAtsushi Nanashima, NagasakiTakuma Nomiya, ChibaKojun Okamoto, HidakaYoungjin Park, SendaiHidefumi Sasaki, TokyoHirotomo Shibaguchi, FukuokaKoichi Suzuki, SaitamaKazuki Takakura, TokyoYoshifumi Takei, NagoyaToshihiko Torigoe, SapporoMasahiko Watanabe, KanagawaHiroko Yamashita, SapporoShozo Yokoyama, WakayamaKazuhiro Yoshida, GifuYoichiro Yoshida, Fukuoka

Malaysia

Batoul Sadat Haerian, Kuala LumpurChee-Onn Leong, Kuala LumpurShing Cheng Tan, Kubang Kerian

Netherlands

Vikram Rao Bollineni, GroningenElisa Giovannetti, AmsterdamLukas Hawinkels, LeidenMartijn Ruben Meijerink, AmsterdamGodefridus J Peters, AmsterdamJudith Evelyn Raber-Durlacher, AmsterdamPieter Christiaan van der Sluis, UtrechtAstrid AM van der Veldt, Amsterdam

Norway

Ingfrid S Haldorsen, Bergen

Line Merethe Oldervoll, TrondheimShanbeh Zienolddiny, Oslo

Peru

Carlos A Castaneda, Lima

Poland

Antoni Mariusz Szczepanik, Cracow

Portugal

Antonio MF Araujo, PortoAna Cristina Ramalhinho, Covilha

Qatar

Julie VCM Decock, Doha

Romania

Valeriu Marin Surlin, Craiova

Russia

Alex Lyakhovich, Novosibirsk

Saudi Arabia

Mostafa Ahmed Arafa, RiyadhZiyad Binkhathlan, RiyadhMazen Hassanain, Riyadh

Singapore

Eddie Yin Kwee Ng, SingaporeVeronique Kiak Mien Tan, Singapore

South Korea

Cheol-Hee Choi, GwangjuIk-Soon Jang, DaejeonChaeyong Jung, GwangjuJong Duk Kim, DaejeonGwang Ha Kim, BusanEun Ju Kim, SeoulLee Su Kim, AnyangHee Sung Kim, SeoulKwang dong Kim, JinjuSang Moo Lim, SeoulSeong Woo Yoon, SeoulDae Young Zang, Anyang-si

Spain

Emiliano Calvo, MadridManuel Fuentes, SalamancaEnrique Grande, MadridMatilde Esther Lleonart, Barcelona

II February 10, 2015WJCO|www.wjgnet.com

III February 10, 2015WJCO|www.wjgnet.com

Jos Antonio Lopez-Guerrero, ValenciaGracia Merino, LeonJordi Muntane, SevilleErnest Nadal, L'HospitaletAmalia Palacios-Eito, CordobaIsabel T Rubio, BarcelonaAlbert Selva-O'Callaghan, Barcelona

Sri Lanka

Kemal I Deen, Dehiwela

Sweden

Yihai Cao, StockholmHong Xie, Stockholm

Switzerland

Nicolas C Buchs, Geneva

Syria

Roger von Moos, Chur

Turkey

Ahmet Altun, SivasBeste Atasoy, IstanbulAhmet Dirier, GaziantepOzkan Kanat, BursaSerhan Kupeli, AdanaKazim Sahin, ElazigIsik G Yulug, Ankara

United Kingdom

Andrew Gaya, London

Konstantinos Lasithiotakis, YorkSebastian Oltean, Bristol

United States

ARM Ruhul Amin, AtlantaSoley Bayraktar, ArdmoreAmer Beitinjaneh, CharlottesvilleMaurizio Bocchetta, MaywoodDeliang Cao, SpringfieldDaniel VT Catenacci, ChicagoZhe-Sheng Chen, QueensGuan Chen, MilwaukeeDuc Phuc Do, ChicagoCathy Eng, HoustonJeffrey M Farma, PhiladelphiaMarkus H Frank, BostonSidney Wang Fu, WashingtonMei R Fu, New YorkSiqing Fu, HoustonSong Gao, HoustonMamdooh Ghoneum, Los AngelesRuben Rene Gonzalez-Perez, AtlantaRachel Nicole Grisham, New YorkSanjay Gupta, ClevelandGerald M Higa, MorgantownChung-Tsen Hsueh, Loma LindaGK Jayaprakasha, College StationJohnny Kao, West IslipNimmi Singh Kapoor, OrangeArianna L Kim, New YorkMark Alan Klein, MinneapolisSunil Krishnan, HoustonMelanie Haas Kucherlapati, BostonMahmoud N Kulaylat, BuffaloAdeyinka O Laiyemo, WashingtonMarie Catherine Lee, TampaJames W Lillard, AtlantaShiaw-Yih Lin, HoustonWei Liu, FrederickZhao-Jun Liu, MiamiJirong Long, NashvilleJianrong Lu, Gainesville

James L Mulshine, ChicagoRonald B Natale, Los AngelesMatthew E Nielsen, Chapel HillKutluk Oktay, ValhallaChung S Park, FargoTayebeh Pourmotabbed, MemphisRaj Pruthi, Chapel HillJay Dilip Raman, HersheyJianyu Rao, Los AngelesGaiane M Rauch, HoustonWilliam C Reinhold, BethesdaMonica Rizzo, AtlantaEben L Rosenthal, BirminghamJoan J Ryoo, Los AngelesVirgilio S Sacchini, New YorkNeeraj K Saxena, BaltimoreCaner Saygin, ClevelandMasood A Shammas, BostonAmar B Singh, OmahaKhalid Sossey-Alaoui, ClevelandLu-Zhe Sun, San AntonioWeijing Sun, PittsburghViqar Syed, BethesdaLi Tao, FremontAnish Thomas, BethesdaReid Thompson, PhiladelphiaShahid Umar, Kansas CityHuan N Vu, RichmondChong-Zhi Wang, ChicagoBin Wang, ChesterJin Wang, HoustonGuojun Wu, DetroitMichiko Yamagata, WalthamWannian Yang, DanvilleEddy S Yang, BirminghamJennifer Yunyan Zhang, DurhamBin Zhang, New YorkShaying Zhao, AthensJin-Rong Zhou, Boston

Viet Nam

Phuc Van Pham, Ho Chi Minh

Contents Bimonthly Volume 6 Number 6 December 10, 2015

December 10, 2015|Volume 6|ssue 6|WJCO|www.wjgnet.com

World Journal ofClinical OncologyW J C O

EDITORIAL

184 Currentdichotomybetweentraditionalmolecularbiologicalandomicresearchincancerbiologyand

pharmacology

Reinhold WC

189 Currentroleofspacersforprostatecancerradiotherapy

Pinkawa M

194 Neuroendocrinetumorsresistanttomammaliantargetofrapamycininhibitors:Adifficultconversionfrom

biologytotheclinic

Fazio N

198 Inorganicphosphatein

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