Hyena (Spanish) 8.8 serial key or number
Hyena (Spanish) 8.8 serial key or number
Closed Genome Sequences of Seven Histophilus somni Isolates from Beef Calves with Bovine Respiratory Disease Complex.
PubMed
Harhay, Gregory P; Harhay, Dayna M; Bono, James L; Smith, Timothy P L; Capik, Sarah F; DeDonder, Keith D; Apley, Michael D; Lubbers, Brian V; White, Bradley J; Larson, Robert L
2017-10-05
Histophilus somni is a fastidious Gram-negative opportunistic pathogenic Pasteurellaceae that affects multiple organ systems and is one of the principal bacterial species contributing to bovine respiratory disease complex (BRDC) in feed yard cattle. Here, we present seven closed genome sequences isolated from three beef calves showing sign of BRDC.
Antibodies to canine and feline viruses in spotted hyenas (Crocuta crocuta) in the Masai Mara National Reserve.
PubMed
Harrison, Tara M; Mazet, Jonna K; Holekamp, Kay E; Dubovi, Edward; Engh, Anne L; Nelson, Keith; Van Horn, Russell C; Munson, Linda
2004-01-01
Spotted hyenas (Crocuta crocuta) are abundant predators in the Serengeti ecosystem and interact with other species of wild carnivores and domestic animals in ways that could encourage disease transmission. Hyenas also have a unique hierarchical social system that might affect the flow of pathogens. Antibodies to canine distemper virus (CDV), feline immunodeficiency virus (FIV), feline panleukopenia virus/canine parvovirus (FPLV/CPV), feline coronavirus/ feline infectious peritonitis virus (FECV/IPV), feline calicivirus (FCV), and feline herpesvirus 1 (FHV1) have been detected in other Serengeti predators, indicating that these viruses are present in the ecosystem. The purpose of this study was to determine whether spotted hyenas also had been infected with these viruses and to assess risk factors for infection. Serum samples were collected between 1993 and 2001 from 119 animals in a single clan for which behavioral data on social structure were available and from 121 hyenas ill several other clans. All animals resided in the Masai Mara National Reserve. Antibodies to CDV, FIV, FPLV/CPV, FECV/FIPV, FCV, and FHV1 were present in 47%, 3.5%, 81%, 36%, 72%, and 0.5% of study hyenas, respectively. Antibody prevalence was greater in adults for FIV and FECV/FIPV, and being a female of high social rank was a risk factor for FIV. Hyenas near human habitation appeared to be at lower risk to have CDV, FIV, and FECV/FIPV antibodies, whereas being near human habitation increased the risk for FPLV/CPV antibodies. Canine (distemper virus and FECV/FIPV antibody prevalence varied considerably over time, whereas FIV, FPLV/CPV, and FCV had a stable, apparently endemic temporal pattern. These results indicate that hyenas might play a role in the ecology of these viruses in the Serengeti ecosystem. The effect of these viruses on hyena health should be further investigated. The lower prevalence of CDV antibody-positive hyenas near human habitation suggests that reservoirs for CDV other
Altered behavior in spotted hyenas associated with increased human activity
USGS Publications Warehouse
Boydston, Erin E.; Kapheim, Karen M.; Watts, Heather E.; Szykman, Micaela; Holekamp, Kay E.
2003-01-01
To investigate how anthropogenic activity might affect large carnivores, we studied the behaviour of spotted hyenas (Crocuta crocuta) during two time periods. From 1996 to 1998, we documented the ecological correlates of space utilization patterns exhibited by adult female hyenas defending a territory at the edge of a wildlife reserve in Kenya. Hyenas preferred areas near dense vegetation but appeared to avoid areas containing the greatest abundance of prey, perhaps because these were also the areas of most intensive livestock grazing. We then compared hyena behaviour observed in 1996–98 with that observed several years earlier and found many differences. Female hyenas in 1996–98 were found farther from dens, but closer to dense vegetation and to the edges of their territory, than in 1988–90. Recent females also had larger home ranges, travelled farther between consecutive sightings, and were more nocturnal than in 1988–90. Finally, hyenas occurred in smaller groups in 1996–98 than in 1988–90. We also found several changes in hyena demography between periods. We next attempted to explain differences observed between time periods by testing predictions of hypotheses invoking prey abundance, climate, interactions with lions, tourism and livestock grazing. Our data were consistent with the hypothesis that increased reliance on the reserve for livestock grazing was responsible for observed changes. That behavioural changes were not associated with decreased hyena population density suggests the behavioural plasticity typical of this species may protect it from extinction.
Visceral pentastomiasis caused by Armillifer armillatus in a captive striped hyena (Hyaena hyaena) in Chiang Mai Night Safari, Thailand.
PubMed
Dechkajorn, Sakorn; Nomsiri, Raksiri; Boonsri, Kittikorn; Sripakdee, Duanghatai; Sukontason, Kabkaew L; Wannasan, Anchalee; Chailangkarn, Sasisophin; Tiwananthagorn, Saruda
2016-02-01
Visceral pentastomiasis (porocephalosis) caused by Armillifer armillatus larvae was incidentally diagnosed in a female striped hyena (Hyaena hyaena) of unknown age which died unexpectedly in 2013. The hyena had been imported from Tanzania 8years earlier and have been since then in a zoo in Chiang Mai, northern Thailand. Pathological examination revealed visceral nymph migrans of pentastomes throughout the intestine, liver, diaphragm, omentum and mesentery, spleen, kidneys, and urinary bladder. Polymerase chain reaction and sequencing that targeted the pentastomid-specific 18S rRNA gene determined 100% identity with reference sequence for A. armillatus, suggesting that its ova can infect the hyena to serve as an intermediate host for the parasite. Further studies to identify the source of infection, its risk factors, and host range for A. armillatus are important to determine its zoonotic potential and to better prevent and manage the disease to protect animal and human health. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Pathophysiology and new strategies for the treatment of Legg-Calvé-Perthes disease.
PubMed
Kim, Harry K W
2012-04-04
Legg-Calvé-Perthes disease is a juvenile form of idiopathic osteonecrosis of the femoral head that can lead to permanent femoral head deformity and premature osteoarthritis. According to two recent multicenter, prospective cohort studies, current nonoperative and operative treatments have modest success rates of producing a good outcome with a spherical femoral head in older children with Legg-Calvé-Perthes disease. Experimental studies have revealed that the immature femoral head is mechanically weakened following ischemic necrosis. Increased bone resorption and delayed new bone formation, in combination with continued mechanical loading of the hip, contribute to the pathogenesis of the femoral head deformity. Biological treatment strategies to improve the healing process by decreasing bone resorption and stimulating bone formation appear promising in nonhuman preclinical studies.
Legg-Calvé-Perthes disease in a child with osteopetrosis
PubMed Central
Sims, Alex L.; Barwick, Thomas W.; Montgomery, Richard J.
2011-01-01
Osteopetrosis is a rare inherited disorder of bone causing increased bone density. Legg-Calvé-Perthes disease (LCPD), by contrast, is a more common idiopathic condition leading to variable avascular necrosis of the immature femoral head. We present a case of a 5-year-old boy presenting with these co-morbidities. We have found only one previous reference suggesting these two conditions can coexist in the literature. We discuss the basic principles of management of this interesting case. PMID:24765380
Comparative efficacy of tilmicosin versus tulathromycin as a metaphylactic antimicrobial in feedlot calves at moderate risk for respiratory disease.
PubMed
Van Donkersgoed, Joyce; Merrill, John; Hendrick, Steven
2008-01-01
The purpose of this study was to compare the efficacy and cost-effectiveness of tilmicosin (MIC) versus tulathromycin (DRAX) as a metaphylactic antimicrobial in feedlot calves at moderate risk for bovine respiratory disease (BRD). Calves that received DRAX had significantly (P < or = .05) lower initial BRD treatment rates compared with calves that received MIC. However, there were no significant differences in the BRD relapse rate, railer rate, total mortality rate, BRD mortality rate, average daily gain, and dry matter conversion between the two groups. The economic advantage of the MIC group was Can$8.29/animal. Based on these results, while DRAX was more efficacious in reducing initial treatments for BRD in feedlot calves at moderate risk for disease, MIC was more cost-effective. The lower initial BRD treatment costs in the DRAX group did not offset the higher metaphylactic cost of DRAX.
Response to foot-and-mouth disease vaccines in newborn calves. Influence of age, colostral antibodies and adjuvants.
PubMed Central
Sadir, A. M.; Schudel, A. A.; Laporte, O.; Braun, M.; Margni, R. A.
1988-01-01
Oil-emulsified (OE) and aqueous (Aq) vaccines were prepared with the same batch of inactivated A24 8345 foot and mouth disease virus (FMDV). Calves born to vaccinated dams did not respond to the Aq vaccine 30 or 90 days post partum. When the OE vaccine was used on a similar group of calves, no responses were elicited up to 21 days post partum. However, calves 30 or more days old responded like adult cattle to the OE vaccine. When the OE vaccine was used in colostral antibody-free calves 3-30 days old, all animals showed good antibody responses but, in calves vaccinated 3 or 7 days post partum, antibodies were detectable only after a considerable period of time. Our results show that both passively acquired colostral antibodies and age are important in the response of very young calves to FMDV oil vaccines. From a practical point of view, in endemic areas where adult cattle are periodically vaccinated, vaccination of calves between 30 and 60 days post partum with OE vaccines would lead to high levels of herd protection. PMID:2828089
Steppe lion remains imported by Ice Age spotted hyenas into the Late Pleistocene Perick Caves hyena den in northern Germany
NASA Astrophysics Data System (ADS)
Diedrich, Cajus G.
2009-05-01
Upper Pleistocene remains of the Ice Age steppe lion Panthera leo spelaea (Goldfuss, 1810) have been found in the Perick Caves, Sauerland Karst, NW Germany. Bones from many hyenas and their imported prey dating from the Lower to Middle Weichselian have also been recovered from the Perick Cave hyena den. These are commonly cracked or exhibit deep chew marks. The absence of lion cub bones, in contrast to hyena and cave bear cub remains in the Perick Caves, and other caves of northern Germany, excludes the possibility that P. leo spelaea used the cave for raising cubs. Only in the Wilhelms Cave was a single skeleton of a cub found in a hyena den. Evidence of the chewing, nibbling and cracking of lion bones and crania must have resulted from the importation and destruction of lion carcasses (4% of the prey fauna). Similar evidence was preserved at other hyena den caves and open air sites in Germany. The bone material from the Perick and other Central European caves points to antagonistic hyena and lion conflicts, similar to clashes of their modern African relatives.
Hip arthroscopy for Legg-Calvè-Perthes disease: minimum 2-year follow-up.
PubMed
Freeman, Carl R; Jones, Kay; Byrd, J W Thomas
2013-04-01
The purpose of this study is to report the results of arthroscopy for the treatment of adolescents and adults with hip pain cause by sequelae of Legg-Calvè-Perthes disease. All patients undergoing hip arthroscopy were prospectively assessed with the modified Harris Hip Score at 3, 6, 12, 24, 60, 120, and 180 months. We identified a cohort of 22 consecutive patients (23 hips) with Legg-Calvè-Perthes disease who had undergone arthroscopy with at least 2-year follow-up; this cohort represents the substance of this report. There was 100% follow-up at 24 months (range, 24 to 180 months). The median age was 27 years (range, 7 to 58 years) with 14 male and 8 female patients. Findings during arthroscopy included 18 labral tears, 17 hypertrophic or torn ligamentum teres, 9 femoral and 8 acetabular chondral lesions, 5 loose bodies, 3 osteochondral defects, and 2 cam lesions. The mean improvement at 24 months was 28 points (56.7 preoperatively and 82 postoperatively). All patients were improved, although this improvement was negligible in 2 patients who underwent repeat arthroscopy. There were no complications. This series reports the results of arthroscopy for Legg-Calvè-Perthes disease and reflects that it does have a role in the management of painful sequelae. Successful outcomes can often be expected with minimal morbidity. Reduced symptoms and improved quality of life are reasonable expectations, although these data do not suggest that hip arthroscopy alters the natural history of the disease process. Level IV, therapeutic case series. Published by Elsevier Inc.
Evaluation of the effects of colostrum replacer supplementation of the milk replacer ration on the occurrence of disease, antibiotic therapy, and performance of pre-weaned dairy calves.
PubMed
Chamorro, Manuel F; Cernicchiaro, Natalia; Haines, Deborah M
2017-02-01
The objective of this study was to evaluate the effects of colostrum supplementation of the milk replacer ration on disease occurrence, antibiotic therapy, and performance of pre-weaned dairy calves with adequate transfer of passive immunity. Two hundred and two 1-d-old Holstein dairy calves were assigned to 1 of 2 groups after arrival to a dairy calf rearing facility. Calves assigned to the control group (n = 100) received milk replacer (28% crude protein and 20% crude fat) without colostrum inclusion twice daily. Calves assigned to the treatment group (n = 102) received 150 g of supplemental colostrum replacer powder added to their milk replacer twice daily for the first 14 d of life. Before group assignment, serum samples were collected from all calves to confirm transfer of passive immunity. Calves were evaluated daily until weaning (56 d of life) for signs of clinical disease as well as any treatment with antibiotics. Presentation of clinical disease and antibiotic treatment was recorded daily by personnel blinded to treatment allocation. Adequate transfer of passive immunity was confirmed in all calves at the start of the study and mean serum IgG values were similar among calves from treatment and control groups. The odds ratios of having abnormal feces and abnormal respiration during the pre-weaning period for calves from the treatment group were 0.15 and 0.46 the odds ratios of calves from the control group, respectively. The odds ratios of receiving antibiotic therapy during the pre-weaning period for calves from the treatment group were 0.09 the odds ratios of calves from the control group. Mean body weight and average daily gain at weaning were not significantly different among calves from the treatment and control groups. Colostrum replacer supplementation of the milk replacer ration was effective in reducing antibiotic therapy and occurrence of disease during the pre-weaning period. Copyright © 2017 American Dairy Science Association. Published by
Growth disturbance in Legg-Calvé-Perthes disease and the consequences of surgical treatment.
PubMed
Leitch, J M; Paterson, D C; Foster, B K
1991-01-01
Seventy-two patients with Legg-Calvé-Perthes disease were studied to assess the interference with proximal femoral growth as a result of the disease itself and of surgical treatment. Twenty-five patients were treated nonoperatively, 20 were treated by femoral varus derotation osteotomy, and 27 by innominate osteotomy. All patients were studied clinically for evidence of abductor weakness and leg-length discrepancy. They were also studied roentgenographically for evidence of femoral head deformity and trochanteric overgrowth. The overall results showed a 6% incidence of leg-length discrepancy greater than 2 cm after both operative and nonoperative treatment. The articulo-trochanteric distance (ATD) was less than +5 mm in 23% of patients, of which 43% had a positive Trendelenburg sign. A significantly lower mean ATD was found in patients treated by femoral varus osteotomy, which should be avoided in patients over eight years of age. The study also demonstrated a strong association between coxa magna and growth disturbance of the proximal femoral physis manifesting itself as either a leg-length discrepancy or as a low ATD. The significant effects of growth disturbance after treatment must be considered, as well as the sphericity of the healed femoral head, in the final assessment in Legg-Calvé-Perthes disease.
Innovative problem solving by wild spotted hyenas
PubMed Central
Benson-Amram, Sarah; Holekamp, Kay E.
2012-01-01
Innovative animals are those able to solve novel problems or invent novel solutions to existing problems. Despite the important ecological and evolutionary consequences of innovation, we still know very little about the traits that vary among individuals within a species to make them more or less innovative. Here we examine innovative problem solving by spotted hyenas (Crocuta crocuta) in their natural habitat, and demonstrate for the first time in a non-human animal that those individuals exhibiting a greater diversity of initial exploratory behaviours are more successful problem solvers. Additionally, as in earlier work, we found that neophobia was a critical inhibitor of problem-solving success. Interestingly, although juveniles and adults were equally successful in solving the problem, juveniles were significantly more diverse in their initial exploratory behaviours, more persistent and less neophobic than were adults. We found no significant effects of social rank or sex on success, the diversity of initial exploratory behaviours, behavioural persistence or neophobia. Our results suggest that the diversity of initial exploratory behaviours, akin to some measures of human creativity, is an important, but largely overlooked, determinant of problem-solving success in non-human animals. PMID:22874748
Respiratory disease in calves: microbiological investigations on trans-tracheally aspirated bronchoalveolar fluid and acute phase protein response.
PubMed
Angen, Oystein; Thomsen, John; Larsen, Lars Erik; Larsen, Jesper; Kokotovic, Branko; Heegaard, Peter M H; Enemark, Jörg M D
2009-05-28
Trans-tracheal aspirations from 56 apparently healthy calves and 34 calves with clinical signs of pneumonia were collected in six different herds during September and November 2002. The 90 samples were cultivated and investigated by PCR tests targeting the species Histophilus somni, Mannheimia haemolytica, Pasteurella multocida, Mycoplasma bovis, Mycoplasma dispar, and Mycoplasma bovirhinis. A PCR test amplifying the lktC-artJ intergenic region was evaluated and shown to be specific for the two species M. haemolytica and Mannheimia glucosida. All 90 aspirations were also analyzed for bovine respiratory syncytial virus (BRSV), parainfluenza-3 virus, and bovine corona virus by antigen ELISA. Surprisingly, 63% of the apparently healthy calves harbored potentially pathogenic bacteria in the lower respiratory tract, 60% of these samples contained either pure cultures or many pathogenic bacteria in mixed culture. Among diseasedcalves, all samples showed growth of pathogenic bacteria in the lower respiratory tract. All of these were classified as pure culture or many pathogenic bacteria in mixed culture. A higher percentage of the samples were positive for all bacterial species in the group of diseased animals compared to the clinically healthy animals, however this difference was only significant for M. dispar and M. bovirhinis. M. bovis was not detected in any of the samples. BRSV was detected in diseasedcalves in two herds but not in the clinically healthy animals. Among the diseasedcalves in these two herds a significant increase in haptoglobin and serum amyloid A levels was observed compared to the healthy calves. The results indicate that haptoglobin might be the best choice for detecting disease under field conditions. For H. somni and M. haemolytica, a higher percentage of the samples were found positive by PCR than by cultivation, whereas the opposite result was found for P. multocida. Detection of P. multocida by PCR or cultivation was found to be
Computerized gait analysis in Legg Calvé Perthes disease--analysis of the frontal plane.
PubMed
Westhoff, Bettina; Petermann, Andrea; Hirsch, Mark A; Willers, Reinhart; Krauspe, Rüdiger
2006-10-01
Current follow-up and outcome studies of Legg Calvé Perthes disease (LCPD) are based on subjective measures of function, clinical parameters and radiological changes [Herring JA, Kim HT, Browne RH. Legg-Calvé-Perthes disease. Part II: prospective multicenter study of the effect of treatment on outcome. J Bone Joint Surg 2004;86A:2121-34; Aksoy MC, Cankus MC, Alanay A, Yazici M, Caglar O, Alpaslan AM. Radiological outcome of proximal femoral varus osteotomy for the treatment of lateral pillar group-C. J Pediatr Orthop 2005;14 B:88-91; Kitakoji T, Hattori T, Kitoh H, Katho M, Ishiguro N. Which is a better method for Perthes' disease: femoral varus or Salter osteotomy? Clin Orthop 2005;430:163-170; Joseph B, Rao N, Mulpuri K, Varghese G, Nair S. How does femoral varus osteotomy alter the natural evolution of Perthes' disease. J Pediatr Orthop 2005;14B:10-5; Ishida A, Kuwajima SS, Laredo FJ, Milani C. Salter innominate osteotomy in the treatment of severe Legg-Calvé-Perthes disease: clinical and radiographic results in 32 patients (37 hips) at skeletal maturity. J Pediatr Orthop 2004;24:257-64.]. The objective of this study was to evaluate the frontal plane kinematics and the effect on hip joint loading on the affected side in children with a radiographic diagnosis of LCPD. Computerized, three-dimensional gait analysis was performed in 33 individuals aged > or =5 years (mean 8.0+/-2 years) with unilateral LCPD and no history of previous surgery to the hip or any disorder leading to gait abnormality. Frontal plane kinematics and kinetics were compared to a group of healthy children (n=30, mean age 8.1+/-1.2 years). Hip joint loading was estimated as a function of the hip abductor moment. Subjects with LCPD demonstrated two distinct frontal plane gait patterns, both deviating from normal. Type 1 (n=3) was characterized by a pelvic drop of the swinging limb, a trunk lean in relation to the pelvis towards the stance limb and hip adduction during stance phase and
Molecular and epidemiological characterization of a respiratory disease outbreak in pre-weaned beef calves associated with bovine coronavirus
USDA-ARS?s Scientific Manuscript database
Bovine coronavirus (BCV) is associated with respiratory tract infections in cattle of all ages; however, a temporal study to evaluate the effect of BCV immunity on virus shedding and bovine respiratory disease (BRD) incidence in pre-weaned beef calves has not been reported. Thus, we report here a pr...
Comparison of thoracic auscultation, clinical score, and ultrasonography as indicators of bovine respiratory disease in preweaned dairy calves.
PubMed
Buczinski, S; Forté, G; Francoz, D; Bélanger, A-M
2014-01-01
The diagnostic tools for bovine respiratory disease diagnosis include clinical inspection, thoracic auscultation, and ultrasonography. Thoracic auscultation and clinical examination have limitations in the detection of lung consolidation in dairy calves. Prospective cohort of 106 preweaned calves from 13 different dairy herds (10 with a history of active bovine respiratory disease (BRD) in calves and 3 without suspected BRD problems). Each preweaned calf was clinically inspected using the Wisconsin calf respiratory scoring chart (CRSC) and treatment history was noted. Systematic thoracic auscultation and ultrasonography then were performed, the latter focusing on lung consolidation. Mortality was recorded over a 30-day period. A total of 56 of 106 calves had ultrasonographic evidence of lung consolidation. The sensitivity of thoracic auscultation to detect consolidation was 5.9% (range, 0-16.7%). Only 41.1% (23/33) of calves with consolidated lungs had been treated previously by the producers. When adding CRSC and previous BRD treatment by the producer, sensitivity of detection increased to 71.4% (40/56). The area under the receiver operating characteristics curve was 0.809 (95% CI, 0.721-0.879) for the number of areas within the lungs with consolidation and 0.743 (95% CI, 0.648-0.823) for the maximal depth of consolidation as predictors of death within 1 month after examination. These were not significantly different (P = .06). This study shows that thoracic auscultation is of limited value in diagnosing lung consolidation in calves. Ultrasonographic assessment of the thorax could be a useful tool to assess BRD detection efficiency on dairy farms. Copyright © 2013 by the American College of Veterinary Internal Medicine.
A field investigation of the economic impact of respiratory disease in feedlot calves
PubMed Central
Jim, G. Kee; Booker, Calvin W.; Ribble, Carl S.; Guichon, P. Timothy; Thorlakson, Ben E.
1993-01-01
A trial involving 512 beef calves was conducted in a commercial research feedlot to determine the effect of bovine respiratory disease (BRD) on performance parameters and carcass characteristics. Two hundred and fifty-six calves that were deemed to be “sick” (S) from BRD were allocated to 16 pens and 256 calves that were considered to be “well” (W) were allocated to another 16 pens. The outcome variables that were measured included average daily gain (ADG), daily dry matter intake (DDMI), dry matter intake to gain ratio (DM:G), BRD treatment rate, death loss, carcass traits, and net profit per pen. The data were partitioned into several time intervals including processing (P) to day −1, day 0 to day 27, day 28 to day 55, day 56 to day 83, day 84 to day 111, day 112 to day 139, day 140 to slaughter, day 0 to slaughter (0-Slaugh), and processing to slaughter (P-Slaugh). However, the most important interval was from processing to slaughter. For the interval P-Slaugh, there were no significant (p≥0.05) differences between the S and W groups with respect to ADG and DM:G. Also, for the interval 0-Slaugh, the DDMI was similar for both groups. There were no significant (p≥0.05) differences between the S and W groups for carcass weight, average fat, grade fat, rib eye area, marbling score, cutability estimate, or carcass grade distribution. The BRD treatment rates in the S and W groups were 6.6% and 4.7%, respectively. The mortality rates in the S and W groups were 0.78% and 0.39%, respectively. Also, there were no deaths attributable to BRD in either group. In the economic model, there was no significant (p≥0.05) difference between the S and W groups with respect to net profit per pen. We conclude that this trial did not validate the concept that BRD impacts performance parameters, because a sufficient disease challenge was not present. However, this study provides several observations that will enhance the experimental design of future studies that attempt
[Legg-Calvé-Perthes disease (LCPD). Principles of diagnosis and treatment].
PubMed
Manig, M
2013-10-01
The clinical course of Legg-Calvé-Perthes disease (LCPD) is variable. Diagnosis, nonsurgical and surgical methods of treatment have evolved over many decades, from abduction casts and braces to advanced surgical containment methods which are now the mainstay of treatment. This article presents a general view and a critical evaluation of the literature. The main prognostic factors are patient age at the onset of LCPD, the range of motion and the extent of the necrotic process according to the classification of Herring and Catterall. The main aims of surgical and nonsurgical treatment of LCPD are to prevent prearthrotic deformity of the femoral head, relief of symptoms, containment of the femoral head and restoration of congruence of the hip joint. Each patient needs to be evaluated individually. Every child must receive an adapted treatment and continued follow-up at regular intervals.
Facial injuries following hyena attack in rural eastern Ethiopia.
PubMed
Fell, M J; Ayalew, Y; McClenaghan, F C; McGurk, M
2014-12-01
Hyenas are effective hunters and will consider humans as potential prey if the need and opportunity arise. This study describes the circumstances of hyena attacks, the patterns of injuries sustained, and reconstruction in a resource-poor setting. As part of a charitable surgical mission to Ethiopia in 2012, 45 patients with facial deformities were reviewed, of whom four were victims of hyena attacks. A semi-structured interview was performed to ascertain the circumstances of the attack and the subsequent consequences. The age of the victims at the time of attack varied from 5 to 50 years. The attacks occurred when the victims were alone and vulnerable and took place in outdoor open spaces, during the evening or at night. The initial lunge was made to the facial area; if the jaws closed on the facial bones they were crushed, but in all cases the soft tissues were grasped and torn from the underlying bone. Reconstruction was dictated by the extent of soft tissue loss but could normally be obtained by use of local or regional flaps. Hyenas have been shown to attack humans in a predictable way and cause injuries that typically involve the soft tissues of the face. Copyright © 2014 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.
South Africa
 Show globe Show map of Africa | |
| Capital | |
| Largest city | Johannesburg[4] |
| Official languages | 11 languages[1] |
| Ethnic groups | |
| Religion | |
| Demonym(s) | South African |
| Government | Unitarydominant-partyparliamentary republic with an executive presidency |
| Cyril Ramaphosa | |
| David Mabuza | |
| Amos Masondo | |
| Thandi Modise | |
| Legislature | Parliament |
| National Council | |
| National Assembly | |
| Independence | |
| 31 May 1910 | |
| 11 December 1931 | |
| 31 May 1961 | |
| 27 April 1994 | |
| 4 February 1997 | |
| Area | |
| 1,221,037 km2 (471,445 sq mi) (24th) | |
| 0.380 | |
| Population | |
| 59,622,350[8] (24th) | |
| 51,770,560[9]:18 | |
| 42.4/km2 (109.8/sq mi) (169th) | |
| GDP (PPP) | 2020 estimate |
 $833.996 billion[10] (32nd) | |
| $13,965[10] (96th) | |
| GDP (nominal) | 2020 estimate |
| $369.854 billion[10] (35th) | |
| $6,193[10] (89th) | |
| Gini (2014) |  63.0[11]very high |
| HDI (2018) | 0.705[12] high · 113th |
| Currency | South African rand (ZAR) |
| Time zone | UTC+2 (SAST) |
| Driving side | left |
| Calling code | +27 |
| ISO 3166 code | ZA |
| Internet TLD | .za |
South Africa, officially the Republic of South Africa (RSA), is the southernmost country in Africa. With over 59 million people, it is the world's 24th-most populous nation and covers an area of 1,221,037 square kilometres (471,445 sq mi). South Africa has three capital cities: executive Pretoria, judicial Bloemfontein and legislative Cape Town. The largest city is Johannesburg. About 80% of South Africans are of Black African ancestry,[9] divided among a variety of ethnic groups speaking different African languages.[13] The remaining population consists of Africa's largest communities of European, Asian, and multiracial ancestry.
It is bounded to the south by 2,798 kilometres (1,739 mi) of coastline of Southern Africa stretching along the South Atlantic and Indian Oceans;[14][15][13] to the north by the neighbouring countries of Namibia, Botswana, and Zimbabwe; and to the east and northeast by Mozambique and Eswatini (former Swaziland); and it surrounds the enclaved country of Lesotho.[16] It is the southernmost country on the mainland of the Old World or the Eastern Hemisphere, and the most populous country located entirely south of the equator.
South Africa is a multiethnic society encompassing a wide variety of cultures, languages, and religions. Its pluralistic makeup is reflected in the constitution's recognition of 11 official languages, the fourth-highest number in the world.[13] According to the 2011 census, the two most spoken first languages are Zulu (22.7%) and Xhosa (16.0%).[9] The two next ones are of European origin: Afrikaans (13.5%) developed from Dutch and serves as the first language of most coloured and white South Africans; English (9.6%) reflects the legacy of British colonialism, and is commonly used in public and commercial life. The country is one of the few in Africa never to have had a coup d'état, and regular elections have been held for almost a century. However, the vast majority of black South Africans were not enfranchised until 1994.
During the 20th century, the black majority sought to claim more rights from the dominant white minority, which played a large role in the country's recent history and politics. The National Party imposed apartheid in 1948, institutionalising previous racial segregation. After a long and sometimes violent struggle by the African National Congress (ANC) and other anti-apartheid activists both inside and outside the country, the repeal of discriminatory laws began in the mid-1980s. Since 1994, all ethnic and linguistic groups have held political representation in the country's liberal democracy, which comprises a parliamentary republic and nine provinces. South Africa is often referred to as the "rainbow nation" to describe the country's multicultural diversity, especially in the wake of apartheid.[17]
South Africa is a developing country and ranks 113th on the Human Development Index, the seventh-highest in Africa. It has been classified by the World Bank as a newly industrialised country, with the second-largest economy in Africa, and the 33rd-largest in the world.[18][19] South Africa also has the most UNESCO World Heritage Sites in Africa. The country is a middle power in international affairs; it maintains significant regional influence and is a member of both the Commonwealth of Nations and G20.[20][21] However, crime, poverty and inequality remain widespread, with about a quarter of the population unemployed and living on less than US$1.25 a day.[22][23]
Name
The name "South Africa" is derived from the country's geographic location at the southern tip of Africa. Upon formation, the country was named the Union of South Africa in English and Unie van Zuid-Afrika in Dutch, reflecting its origin from the unification of four formerly separate British colonies. Since 1961, the long formal name in English has been the "Republic of South Africa" and Republiek van Suid-Afrika in Afrikaans. Since 1994, the country has had an official name in each of its 11 official languages.
Mzansi, derived from the Xhosa noun umzantsi meaning "south", is a colloquial name for South Africa,[24][25] while some Pan-Africanist political parties prefer the term "Azania".[26]
History
Prehistoric archaeology
South Africa contains some of the oldest archaeological and human-fossil sites in the world.[27][28][29] Archaeologists have recovered extensive fossil remains from a series of caves in Gauteng Province. The area, a UNESCOWorld Heritage site, has been branded "the Cradle of Humankind". The sites include Sterkfontein, one of the richest sites for hominin fossils in the world. Other sites include Swartkrans, Gondolin CaveKromdraai, Coopers Cave and Malapa. Raymond Dart identified the first hominin fossil discovered in Africa, the Taung Child (found near Taung) in 1924. Further hominin remains have come from the sites of Makapansgat in Limpopo Province, Cornelia and Florisbad in the Free State Province, Border Cave in KwaZulu-Natal Province, Klasies River Mouth in Eastern Cape Province and Pinnacle Point, Elandsfontein and Die Kelders Cave in Western Cape Province.
These finds suggest that various hominid species existed in South Africa from about three million years ago, starting with Australopithecus africanus.[30] There followed species including Australopithecus sediba, Homo ergaster, Homo erectus, Homo rhodesiensis, Homo helmei, Homo naledi and modern humans (Homo sapiens). Modern humans have inhabited Southern Africa for at least 170,000 years.
Various researchers have located pebble tools within the Vaal River valley.[31][32]
Bantu expansion
Settlements of Bantu-speaking peoples, who were iron-using agriculturists and herdsmen, were already present south of the Limpopo River (now the northern border with Botswana and Zimbabwe) by the 4th or 5th century CE (see Bantu expansion). They displaced, conquered and absorbed the original Khoisan speakers, the Khoikhoi and San peoples. The Bantu slowly moved south. The earliest ironworks in modern-day KwaZulu-Natal Province are believed to date from around 1050. The southernmost group was the Xhosa people, whose language incorporates certain linguistic traits from the earlier Khoisan people. The Xhosa reached the Great Fish River, in today's Eastern Cape Province. As they migrated, these larger Iron Age populations displaced or assimilated earlier peoples. In Mpumalanga Province, several stone circles have been found along with the stone arrangement that has been named Adam's Calendar, the ruins are thought to be created by the Bakone a Northern Sotho people.[33][34]
Portuguese exploration
At the time of European contact, the dominant ethnic group were Bantu-speaking peoples who had migrated from other parts of Africa about one thousand years before. The two major historic groups were the Xhosa and Zulu peoples.
In 1487, the Portuguese explorer Bartolomeu Dias led the first European voyage to land in southern Africa.[35] On 4 December, he landed at Walfisch Bay (now known as Walvis Bay in present-day Namibia). This was south of the furthest point reached in 1485 by his predecessor, the Portuguese navigator Diogo Cão (Cape Cross, north of the bay). Dias continued down the western coast of southern Africa. After 8 January 1488, prevented by storms from proceeding along the coast, he sailed out of sight of land and passed the southernmost point of Africa without seeing it. He reached as far up the eastern coast of Africa as, what he called, Rio do Infante, probably the present-day Groot River, in May 1488, but on his return he saw the Cape, which he first named Cabo das Tormentas (Cape of Storms). His King, John II, renamed the point Cabo da Boa Esperança, or Cape of Good Hope, as it led to the riches of the East Indies.[36] Dias' feat of navigation was later immortalised in Luís de Camões' Portuguese epic poem, The Lusiads (1572).
Dutch colonisation
By the early 17th century, Portugal's maritime power was starting to decline, and English and Dutch merchants competed to oust Lisbon from its lucrative monopoly on the spice trade.[37] Representatives of the British East India Company did call sporadically at the Cape in search of provisions as early as 1601, but later came to favour Ascension Island and St. Helena as alternative ports of refuge.[38] Dutch interest was aroused after 1647, when two employees of the Dutch East India Company (VOC) were shipwrecked at the Cape for several months. The sailors were able to survive by obtaining fresh water and meat from the natives.[38] They also sowed vegetables in the fertile soil.[39] Upon their return to Holland, they reported favourably on the Cape's potential as a "warehouse and garden" for provisions to stock passing ships for long voyages.[38]
In 1652, a century and a half after the discovery of the Cape sea route, Jan van Riebeeck established a victualling station at the Cape of Good Hope, at what would become Cape Town, on behalf of the Dutch East India Company.[40][41] In time, the Cape became home to a large population of vrijlieden, also known as vrijburgers (lit. 'free citizens'), former company employees who stayed in Dutch territories overseas after serving their contracts.[41] Dutch traders also imported thousands of slaves to the fledgling colony from Indonesia, Madagascar, and parts of eastern Africa.[42] Some of the earliest mixed race communities in the country were formed through unions between vrijburgers, their slaves, and various indigenous peoples.[43] This led to the development of a new ethnic group, the Cape Coloureds, most of whom adopted the Dutch language and Christian faith.[43]
The eastward expansion of Dutch colonists ushered in a series of wars with the southwesterly migrating Xhosa tribe, known as the Xhosa Wars, as both sides competed for the pastureland necessary to graze their cattle near the Great Fish River.[44]Vrijburgers who became independent farmers on the frontier were known as Boers, with some adopting semi-nomadic lifestyles being denoted as trekboers.[44] The Boers formed loose militias, which they termed commandos, and forged alliances with Khoisan groups to repel Xhosa raids.[44] Both sides launched bloody but inconclusive offensives, and sporadic violence, often accompanied by livestock theft, remained common for several decades.[44]
British colonisation and the Great Trek
Great Britain occupied Cape Town between 1795 and 1803 to prevent it from falling under the control of the French First Republic, which had invaded the Low Countries.[44] Despite briefly returning to Dutch rule under the Batavian Republic in 1803, the Cape was occupied again by the British in 1806.[45] Following the end of the Napoleonic Wars, it was formally ceded to Great Britain and became an integral part of the British Empire.[46] British emigration to South Africa began around 1818, subsequently culminating in the arrival of the 1820 Settlers.[46] The new colonists were induced to settle for a variety of reasons, namely to increase the size of the European workforce and to bolster frontier regions against Xhosa incursions.[46]
In the first two decades of the 19th century, the Zulu people grew in power and expanded their territory under their leader, Shaka.[47] Shaka's warfare indirectly led to the Mfecane ("crushing"), in which 1,000,000 to 2,000,000 people were killed and the inland plateau was devastated and depopulated in the early 1820s.[48][49] An offshoot of the Zulu, the Matabele people created a larger empire that included large parts of the highveld under their king Mzilikazi.
During the early 1800s, many Dutch settlers departed from the Cape Colony, where they had been subjected to British control, in a series of migrant groups who came to be known as Voortrekkers, meaning "Pathfinders" or "Pioneers". They migrated to the future Natal, Free State, and Transvaal regions. The Boers founded the Boer Republics: the South African Republic (now Gauteng, Limpopo, Mpumalanga and North West provinces), the Natalia Republic (KwaZulu-Natal), and the Orange Free State (Free State).
The discovery of diamonds in 1867 and gold in 1884 in the interior started the Mineral Revolution and increased economic growth and immigration. This intensified British efforts to gain control over the indigenous peoples. The struggle to control these important economic resources was a factor in relations between Europeans and the indigenous population and also between the Boers and the British.[50]
On 16 May 1876, President Thomas François Burgers of the South African Republic (Transvaal) declared war against Sekhukhune and the Pedi. Sekhukhune managed to defeat the Transvaal army on 1 August 1876. Another attack by the Lydenburg Volunteer Corps was also repulsed. On 16 February 1877, the two parties signed a peace treaty at Botshabelo.[51] The Boers inability to subdue Sekhukhune and the Pedi led to the departure of Burgers in favour of Paul Kruger and the British annexation of the South African Republic(Transvaal) on 12 April 1877 by Sir Theophilus Shepstone, secretary for native affairs of Natal. In 1878 and 1879 three British attacks were successfully repelled until Sir Garnet Wolseley defeated Sekhukhune in November 1879 with an army of 2,000 British soldiers, Boers and 10,000 Swazis.
The Anglo-Zulu War was fought in 1879 between the United Kingdom and the Zulu Kingdom. Following Lord Carnarvon's successful introduction of federation in Canada, it was thought that similar political effort, coupled with military campaigns, might succeed with the African kingdoms, tribal areas and Boer republics in South Africa. In 1874, Sir Henry Bartle Frere was sent to South Africa as the British High Commissioner to bring such plans into being. Among the obstacles were the presence of the independent states of the Boers and the Kingdom of Zululand and its army. The Zulu nation defeated the British at the Battle of Isandlwana. Eventually, though, the war was lost, resulting in the termination of the Zulu nation's independence.
Boer Wars
The Boer Republics successfully resisted British encroachments during the First Boer War (1880–1881) using guerrilla warfare tactics, which were well suited to local conditions. The British returned with greater numbers, more experience, and new strategy in the Second Boer War (1899–1902) but suffered heavy casualties through attrition; nonetheless, they were ultimately successful. Over 27,000 Boer women and children perished in the British concentration camps.[52]
Independence
Within the country, anti-British policies among white South Africans focused on independence. During the Dutch and British colonial years, racial segregation was mostly informal, though some legislation was enacted to control the settlement and movement of native people, including the Native Location Act of 1879 and the system of pass laws.[53][54][55][56][57]
Eight years after the end of the Second Boer War and after four years of negotiation, an act of the British Parliament (South Africa Act 1909) granted nominal independence, while creating the Union of South Africa on 31 May 1910. The Union was a dominion that included the former territories of the Cape, Transvaal and Natal colonies, as well as the Orange Free State republic.[58]
The Natives' Land Act of 1913 severely restricted the ownership of land by blacks; at that stage natives controlled only seven percent of the country. The amount of land reserved for indigenous peoples was later marginally increased.[59]
In 1931, the union was fully sovereign from the United Kingdom with the passage of the Statute of Westminster, which abolished the last powers of the British Government on the country. In 1934, the South African Party and National Party merged to form the United Party, seeking reconciliation between Afrikaners and English-speaking whites. In 1939, the party split over the entry of the Union into World War II as an ally of the United Kingdom, a move which the National Party followers strongly opposed.
Beginning of apartheid
In 1948, the National Party was elected to power. It strengthened the racial segregation begun under Dutch and British colonial rule. Taking Canada's Indian Act as a framework,[60] the nationalist government classified all peoples into three races and developed rights and limitations for each. The white minority (less than 20%)[61] controlled the vastly larger black majority. The legally institutionalised segregation became known as apartheid. While whites enjoyed the highest standard of living in all of Africa, comparable to First World Western nations, the black majority remained disadvantaged by almost every standard, including income, education, housing, and life expectancy. The Freedom Charter, adopted in 1955 by the Congress Alliance, demanded a non-racial society and an end to discrimination.
Republic
On 31 May 1961, the country became a republic following a referendum (only open to white voters) which narrowly passed; the British-dominated Natal province largely voted against the proposal.[62]Queen Elizabeth II lost the title Queen of South Africa, and the last Governor-General, Charles Robberts Swart, became State President. As a concession to the Westminster system, the appointment of the president remained an appointment by parliament, and virtually powerless until P. W. Botha's Constitution Act of 1983, which eliminated the office of Prime Minister and instated a near-unique "strong presidency" responsible to parliament. Pressured by other Commonwealth of Nations countries, South Africa withdrew from the organisation in 1961 and rejoined it only in 1994.
Despite opposition both within and outside the country, the government legislated for a continuation of apartheid. The security forces cracked down on internal dissent, and violence became widespread, with anti-apartheid organisations such as the African National Congress (ANC), the Azanian People's Organisation (AZAPO), and the Pan-Africanist Congress (PAC) carrying out guerrilla warfare[63] and urban sabotage.[64] The three rival resistance movements also engaged in occasional inter-factional clashes as they jockeyed for domestic influence.[65] Apartheid became increasingly controversial, and several countries began to boycott business with the South African government because of its racial policies. These measures were later extended to international sanctions and the divestment of holdings by foreign investors.[66][67]
In the late 1970s, South Africa initiated a programme of nuclear weapons development. In the following decade, it produced six deliverable nuclear weapons.[68][69]
End of apartheid
The Mahlabatini Declaration of Faith, signed by Mangosuthu Buthelezi and Harry Schwarz in 1974, enshrined the principles of peaceful transition of power and equality for all, the first of such agreements by black and white political leaders in South Africa. Ultimately, FW de Klerk opened bilateral discussions with Nelson Mandela in 1993 for a transition of policies and government.
In 1990, the National Party government took the first step towards dismantling discrimination when it lifted the ban on the ANC and other political organisations. It released Nelson Mandela from prison after 27 years' serving a sentence for sabotage. A negotiation process followed. With approval from the white electorate in a 1992 referendum, the government continued negotiations to end apartheid. South Africa also destroyed its nuclear arsenal and acceded to the Nuclear Non-Proliferation Treaty. South Africa held its first universal elections in 1994, which the ANC won by an overwhelming majority. It has been in power ever since. The country rejoined the Commonwealth of Nations and became a member of the Southern African Development Community (SADC).
In post-apartheid South Africa, unemployment remained high. While many blacks have risen to middle or upper classes, the overall unemployment rate of black people worsened between 1994 and 2003 by official metrics, but declined significantly using expanded definitions.[70] Poverty among whites, which was previously rare, increased.[71] In addition, the current government has struggled to achieve the monetary and fiscal discipline to ensure both redistribution of wealth and economic growth. The United Nations (UN) Human Development Index (HDI) of South Africa fell from 1995 to 2005, while it was steadily rising until the mid-1990s,[72] before recovering its 1995 peak in 2013.[73] This is in large part attributable to the South African HIV/AIDS pandemic which saw South African life expectancy fall from a high point of 62.25 years in 1992 to a low of 52.57 in 2005,[74] and the failure of the government to take steps to address the pandemic in its early years.[75]
In May 2008, riots left over 60 people dead.[76] The Centre on Housing Rights and Evictions estimated that over 100,000 people were driven from their homes.[77] The targets were mainly legal and illegal migrants and refugees seeking asylum, but a third of the victims were South African citizens.[76] In a 2006 survey, the South African Migration Project concluded that South Africans are more opposed to immigration than any other national group.[78] The UN High Commissioner for Refugees in 2008 reported over 200,000 refugees applied for asylum in South Africa, almost four times as many as the year before.[79] These people were mainly from Zimbabwe, though many also come from Burundi, Democratic Republic of the Congo, Rwanda, Eritrea, Ethiopia and Somalia.[79] Competition over jobs, business opportunities, public services and housing has led to tension between refugees and host communities.[79]
Total System Administration
Click here for a list of new features in v14.0!
Using the built-in Windows administration tools to manage a medium to large Windows network or Active Directory environment can be a challenge. Add multiple domains, hundreds or thousands of servers, workstations, and users, and before you know it, things can get out of hand. Hyena is designed to both simplify and centralize nearly all of the day-to-day management tasks, while providing new capabilities for system administration. This functionality is provided in a single, centralized, easy to use product. Used today by tens of thousands of system administrators worldwide, Hyena is the one tool that every administrator cannot afford to be without.
Hyena uses an Explorer-style interface for all operations, including right mouse click pop-up context menus for all objects. Management of users, groups (both local and global), shares, domains, computers, services, devices, events, files, printers and print jobs, sessions, open files, disk space, user rights, messaging, exporting, job scheduling, processes, and printing are all supported. For an example of a typical enterprise-wide view in Hyena, click here.
Review: SystemTools Hyena - Simplify Active Directory Management
Hyena includes Active Directory tools for Windows 10. In fact, Hyena can be used on any Windows client to manage any Windows NT, Windows 2000, Windows XP/Vista, Windows 7, Windows 8, Windows 8.1, Windows 10 or Windows Server 2003/2008/2012/2016/2019 installation.
In addition to supporting standard Windows system management functions, Hyena also includes extensive Active Directory support and management tools.
The key new feature in Hyena is the 'Active Task'. Hyena's new 'Active Task' will provide the functionality for mass importing and updating of most Active Directory attributes from a delimited text input file.
All task settings are saved in a 'task file', allowing for easy repetitive task executions, including command line and scheduling support. For Active Directory user tasks, home directory creation can be automated using Hyena's existing user home directory templates.
Click here for more information on the new 'Active Task' feature.
Hyena also includes:
Full exporting capabilities with both Microsoft Access and Excel reporting and exporting options.
*Exchange 2007: mailbox properties management only.
Hyena's cost effective licensing policy is based on the number of administrators actually using the product, regardless of the number of end-users or servers. The 30-day evaluation copy is fully functional and free support is available both during and after the evaluation period.
To find out more about Hyena's different management areas, select one of the categories below:
If you are already familiar with Hyena's main features, see what's in store in the latest release, Hyena v14.0
What’s New in the Hyena (Spanish) 8.8 serial key or number?
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